PEARL™: The Future of Skin Rejuvenation with Salmon DNA, Exosomes & Microneedling
- Renee Topala
- Feb 4
- 3 min read
Introducing PEARL™
Salmon DNA with Exosomes & Growth Factors Microneedling
The ultimate in skin rejuvenation
At Advanced Aesthetics Group, we are always looking beyond trends and toward true skin biology—treatments that work with your skin rather than against it. That pursuit led us to PEARL™, a next-generation microneedling experience designed to activate regeneration at the cellular level.
PEARL™ combines salmon-derived DNA (PDRN) with exosomes and growth factors, delivered through medical microneedling to trigger deep repair, collagen stimulation, and visible rejuvenation.
This is not just about glowing skin for a few days.This is about stronger, healthier skin over time.
What Is PEARL™?
PEARL™ is an advanced regenerative microneedling treatment that infuses bioactive ingredients directly into the skin while creating controlled micro-injuries that stimulate the body’s natural healing response.
The result is a synergistic effect:
Mechanical stimulation from microneedling
Biologic signaling from DNA fragments, exosomes, and growth factors
Long-term improvements in skin quality, not just surface appearance
The Science Behind the Glow
Salmon DNA (PDRN)
PDRN (polydeoxyribonucleotide) is derived from salmon DNA and has been widely studied for its ability to:
Support tissue repair
Improve skin elasticity
Enhance hydration
Reduce inflammation
Promote healthier cell turnover
It works by signaling skin cells to repair and regenerate more efficiently—making it especially powerful for aging, stressed, or compromised skin.
Exosomes
Exosomes are microscopic messengers released by cells that carry growth signals, proteins, and genetic information. In aesthetic medicine, exosomes help:
Improve cellular communication
Accelerate healing
Support collagen and elastin production
Calm inflammatory pathways
Think of them as instruction packets that tell your skin how to behave younger.
Growth Factors
Growth factors amplify the regenerative response by stimulating fibroblasts—the cells responsible for collagen, elastin, and overall skin structure. When combined with microneedling, they penetrate more effectively and work more deeply.
What Can PEARL™ Improve?
PEARL™ is ideal for patients looking to address:
Fine lines and wrinkles
Loss of elasticity and firmness
Dull, tired, or dehydrated skin
Uneven tone or texture
Post-inflammatory changes
Early aging and prevention
Because this treatment supports skin health at a cellular level, it is suitable for a wide range of ages and skin types.
What Makes PEARL™ Different?
Many treatments focus on short-term results—temporary plumping or surface exfoliation. PEARL™ is different.
This is biologic rejuvenation:
Focused on skin integrity, not just appearance
Designed to improve how your skin functions over time
Ideal as a standalone treatment or as part of a comprehensive skin health plan
Patients often describe their skin after PEARL™ as:
“Stronger,” “brighter,” “more resilient,” and “healthier—not just smoother.”
What to Expect
Minimal downtime compared to more aggressive resurfacing
Gradual improvement over weeks as collagen remodels
Best results achieved through a series, depending on goals
Can be paired with other regenerative or collagen-stimulating treatments
Your provider will tailor the treatment plan based on your skin, lifestyle, and long-term goals.
Who Is PEARL™ For?
PEARL™ is ideal if you:
Want natural-looking rejuvenation
Prefer science-backed treatments
Are focused on long-term skin health
Want to prevent aging, not just correct it
Are ready to invest in regenerative aesthetics
Refined. Regenerative. Radiant.
PEARL™ represents the future of microneedling—where technology meets biology to restore skin from within.
If you’re ready to experience next-level skin rejuvenation, we’d love to guide you through whether PEARL™ is right for you.
📍 Now available at Advanced Aesthetics Group
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